2-Hexyl-4-Pentynoic Acid, Catalog: B2834

Alternate Name 2-prop-2-ynyloctanoic acid; 2-Propargyloctanoic Acid

Appearance Oil

CAS # 96017-59-3

Molecular Formula C₁₁H₁₈O₂

Molecular Weight 182.26

Purity ≥ 95%

Solubility ~20 mg/ml in DMSO
 ~16 mg/ml in DMF
 ~33 mg/ml in Ethanol
 ~2mg/ml in PBS, pH 7.2

SMILES CCCCCCC(CC#C)C(=O)O

InChi InChI=1S/C11H18O2/c1-3-5-6-7-9-10(8-4-2)11(12)13/h2,10H,3,5-9H2,1H3,(H,12,13)

InChi Key DUQSBRQHALCSLC-UHFFFAOYSA-N

PubChem CID 175664

MDL Number MFCD00946863

Storage Conditions -20ºC

Shipping Conditions RT

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear gloves and a mask when handling the product! Avoid contact by all modes of exposure.

2-Hexyl-4-Pentynoic Acid is an inhibitor of histone deacetylases (HDACs). It is a derivative of Valproic acid. It inhibits HDAC activity with an IC₅₀ of 13 μM, compared to an IC₅₀ of 398 μM for Valproic acid. It induces histone hyperacetylation at a concentration of 5 μM in cerebellar granule cells and increases HSP70-1a and HSP70-1b mRNA levels at 50 μM. It is neuroprotective against glutamate-induced excitotoxicity.